Nano-engineering of ketorolac tromethamine platforms for ocular treatment of inflammatory disorders

Aim: The development and optimization of Ketorolac tromethamine-loaded polylactic-co-glycolic acid nanoparticles (KT-NPs) for the treatment inflammatory processes eye. Materials & methods: KT-NPs were developed by factorial design characterized assessing their physicochemical properties. Biopharmaceutical behavior studies, ocular tolerance, anti-inflammatory efficacy bioavailability tests performed on pigs. Results: Optimized 112 nm, narrow distribution with encapsulation efficiency near 100% obtained. KT release followed Weibull model there was significantly greater retention in cornea sclera than commercial reference. showed no signs irritancy similar to Conclusion: a suitable alternative disorders anterior posterior segments eye as an conventional topical formulations.